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Updated: Sep 30, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy
Regula S Briellmann1, Samuel F Berkovic, Ari Syngeniotis
1Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia.
Abstract:
This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.

