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Human immunodeficiency virus genotype and hypertriglyceridemia.

Soni J Anderson1, John F Bradley, Andrea Ferreira-Gonzalez

  • 1Department of Pathology, Division of Molecular Diagnostics, Medical College of Virginia, Richmond, Virginia 23298-0248, USA. sjanders@hsc.vcu.edu

Journal of Clinical Laboratory Analysis
|July 12, 2002
PubMed
Summary

HIV patients with hypertriglyceridemia show more mutated viral genotypes. Specific mutations in reverse transcriptase are strongly linked to this condition, suggesting HIV genotype may contribute to lipodystrophy.

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Area of Science:

  • Virology
  • Genetics
  • Metabolic Disorders

Background:

  • Highly active antiretroviral therapy (HAART) is associated with lipodystrophy in HIV patients.
  • This syndrome involves abnormal body fat distribution and hypertriglyceridemia.
  • The exact cause of HAART-associated lipodystrophy remains under investigation.

Purpose of the Study:

  • To investigate the association between HIV genotype and hypertriglyceridemia in patients undergoing HAART.
  • To identify specific HIV genetic mutations linked to the development of hypertriglyceridemia.

Main Methods:

  • Retrospective analysis of viral genotypes from 51 HIV patients.
  • Comparison of genotypes between patients with and without hypertriglyceridemia.
  • Statistical analysis to identify correlations between mutations and hypertriglyceridemia.

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Main Results:

  • HIV patients with hypertriglyceridemia had significantly more mutated viral genotypes.
  • Hypertriglyceridemia was statistically associated with predicted resistance to zidovudine, abacavir, and stavudine.
  • Mutations at reverse transcriptase codons M41 and T215 showed a strong association with hypertriglyceridemia.

Conclusions:

  • HIV genotype may be a significant etiologic factor in antiretroviral-associated lipodystrophy.
  • Specific HIV genetic mutations are linked to hypertriglyceridemia, a component of lipodystrophy.
  • Further research is needed to elucidate the role of HIV genotype in HAART-associated lipodystrophy.