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Related Experiment Videos

Hepatitis C in pregnancy.

M J Dinsmoor1

  • 1Department of Obstetrics and Gynecology, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Room 1600 WH, Evanston, IL 60201, USA.

Current Women'S Health Reports
|July 13, 2002
PubMed
Summary

Hepatitis C virus (HCV) affects 1-4% of pregnant women, with nearly half lacking risk factors. While vertical transmission to newborns occurs at 5%, routine screening isn't recommended due to lack of approved treatments for pregnant women or infants.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Hepatitis C virus (HCV) seroprevalence in pregnant populations in Europe and the US ranges from 1% to 4%.
  • Approximately 50% of infected pregnant women lack identifiable risk factors for HCV.
  • Current guidelines do not recommend routine HCV screening for all pregnant women.

Purpose of the Study:

  • To review the epidemiology of Hepatitis C virus in pregnant women.
  • To assess the risk and factors associated with vertical transmission of HCV.
  • To discuss current recommendations regarding screening and management of HCV in pregnancy.

Main Methods:

  • Review of existing epidemiologic studies on HCV prevalence in pregnant women.
  • Analysis of data on vertical transmission rates and associated risk factors.
  • Evaluation of current clinical recommendations and treatment options.

Main Results:

  • HCV infection is found in 1-4% of pregnant women, often without clear risk factors.
  • Neonatal transmission occurs in about 5% of cases, with transmission timing (in utero or intrapartum) unclear.
  • Concomitant HIV infection and high maternal HCV viral load increase vertical transmission risk.
  • Breastfeeding does not significantly elevate the risk of neonatal HCV infection.

Conclusions:

  • HCV screening in pregnancy is not routinely recommended despite prevalence and asymptomatic infections.
  • Vertical transmission is a concern, influenced by maternal viral load and HIV co-infection.
  • No approved treatments for HCV are available for pregnant women or neonates, highlighting a gap in care.

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