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Related Experiment Videos

H1-antihistamines in asthma.

James L Lordan1, Stephen T Holgate

  • 1University of Southampton, Southampton, England.

Clinical Allergy and Immunology
|July 13, 2002
PubMed
Summary

Second-generation H1-antagonists may help upper and lower airway symptoms in asthma and allergic rhinitis. Combined therapy with antihistamines and antileukotrienes could benefit patients with poor adherence to inhaled corticosteroids.

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Area of Science:

  • Allergy and immunology
  • Pulmonology
  • Pharmacology

Background:

  • Histamine is a key mediator in asthma's early allergic response.
  • While histamine contributes to bronchoconstriction, leukotrienes play a larger role in asthma.
  • Rising global prevalence of allergy and asthma necessitates exploring new therapeutic avenues.

Purpose of the Study:

  • To evaluate the role of H1-antagonists in managing asthma and allergic rhinitis symptoms.
  • To explore the potential of combined antihistamine and antileukotriene therapy.
  • To assess the possibility of H1-antagonists delaying asthma onset in infants.

Main Methods:

  • Review of existing literature on histamine, leukotrienes, and H1-antagonists in respiratory diseases.
  • Analysis of the pharmacological properties and clinical effects of second-generation H1-antagonists.
  • Consideration of therapeutic strategies for patients with coexistent asthma and allergic rhinitis.

Main Results:

  • Second-generation H1-antagonists show improved safety and tolerability with anti-inflammatory and bronchodilator effects.
  • These agents may alleviate upper and lower airway symptoms in patients with mild asthma and allergic rhinitis.
  • Monotherapy with H1-antagonists is unlikely to provide substantial asthma benefit, but combination therapy shows promise.

Conclusions:

  • Second-generation H1-antagonists offer potential benefits for managing coexistent asthma and allergic rhinitis.
  • Combined antihistamine and antileukotriene therapy may be a valuable option for non-adherent patients.
  • Further research is warranted to investigate the potential of H1-antagonists in preventing asthma development in infants.

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