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Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues
Bogdan Walkowiak1, Janina Baraniak, Czeslaw S Cierniewski
1Department of Molecular and Medical Biophysics, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland. bogdan.walkowiak@csk.am.lodz.pl
Bioorganic & Medicinal Chemistry Letters
|July 13, 2002
Abstract:
The synthesis and biological evaluation of new diadenosine polyphosphate analogues on blood platelet aggregation are reported. The most active are compounds with a sulfur atom replacing one or both non-bridging oxygens at phosphorus bound to adenosyl residues and hydroxymethyl groups of bis(hydroxymethyl)phosphinic acid.