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Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1
Ramin Faghih1, Wesley Dwight, Robert Gentles
1Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064-6123, USA. ramin.faghih@abbott.com
Bioorganic & Medicinal Chemistry Letters
|July 13, 2002
Abstract:
SAR studies for novel non-imidazole containing H(3) receptor antagonists with high potency and selectivity for rat H(3) receptors are described. A high throughput screening lead, A-923, was further elaborated in a systematic manner to clarify a pharmacophore for this class of aryloxyalkyl piperazine based compounds.