Related Experiment Video
Updated: Jul 26, 2026
Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
A cephalometric inter-centre comparison of growth in children with cleft lip and palate
Maren J Gaukroger1, J H Noar, R Sanders
1Eastman Dental Institute for Oral Health Care Sciences, University College London, London, UK. mjgaukroger@hotmail.com
Insights
Cleft lip and palate treatment at Mount Vernon resulted in reduced maxillary prominence in 14-16 year olds compared to Oslo. This difference was significant for unilateral cleft lip and palate cases.
Area of Science:
- Craniofacial surgery
- Orthodontics
- Pediatric dentistry
Background:
- Cleft lip and palate treatment aims to optimize craniofacial growth.
- Comparing outcomes between different treatment centers is crucial for clinical practice improvement.
Purpose of the Study:
- To compare the craniofacial growth outcomes of children treated by the Mount Vernon Cleft Team with those treated by the Oslo Team.
- To determine if Mount Vernon's treatment yields comparable results to the Oslo Team's approach.
Main Methods:
- A retrospective cephalometric study was conducted.
- Seventy-five Mount Vernon and 150 Oslo children with complete clefts were matched for age, gender, and cleft type.
- Radiographs were analyzed for craniofacial growth variables, excluding patients with anomalies.
Main Results:
- Significant differences in maxillary growth were observed in bilateral and unilateral cleft groups (ages 14-16).
- Mount Vernon cases exhibited a flatter soft tissue profile and reduced maxillary prominence (3.9-5.1 degrees) compared to the Oslo sample.
- Bilateral cases from Mount Vernon showed greater anterior face heights.
Conclusions:
- Mount Vernon Cleft Team's treatment leads to reduced maxillary prominence in 14-16 year olds compared to the Oslo sample.
- This reduction is statistically significant, particularly in unilateral cleft lip and palate cases.
Aim:
To examine whether the treatment provided by the Mount Vernon Cleft Team produces craniofacial growth outcomes comparable with that of the Oslo Team.
Location:
Mount Vernon Hospital, Middlesex, UK.
Design:
A retrospective cephalometric investigation.
Subjects:
Seventy-five Mount Vernon children and 150 Oslo children with complete unilateral or bilateral clefts of the lip and palate
Method:
The subjects were matched for age, gender, and cleft type, and their radiographs were digitized. The radiographs from each site were grouped according to patient age (9-11 or 14-16) and cleft classification (bilateral/unilateral). Patients with associated craniofacial anomalies were excluded from the study.
Results:
Of the four variables studied (SNA, SNPg, NGn, sNANsPG) significant differences in maxillary growth were noted for bilateral and unilateral cleft groups at 14-16 years of age. The soft tissue profile was significantly flatter in bilateral and unilateral Mount Vernon cases at 14-16 years. The craniofacial growth exhibited by the Mount Vernon patients demonstrated 3.9-5.1 degrees reduction in maxillary prominence with respect to the Oslo sample. The bilateral cases from Mount Vernon had greater anterior face heights at 14-16 years.
Conclusion:
The treatment provided by the Mount Vernon Cleft team leads to a reduced maxillary prominence in children aged 14-16 years compared with the Oslo sample. This reduction is statistically significant in unilateral cleft lip and palate.
