Human Insulinomas: Clinical, Cellular, and Molecular Aspects

Paul Komminoth¹, Philipp U. Heitz, Jürgen Roth

¹MD, PHD.

|July 13, 2002

Insulinoma is the most frequently encountered functioning endocrine pancreatic tumor in humans. In this overview we summarize morphological and clinical features of insulinomas, report about the proinsulin-insulin conversion in normal and neoplastic B-cells, discuss the new classification, the criteria of malignancy, and the clonal composition of endocrine pancreatic tumors, and outline recent findings on the molecular pathology of these tumors.

Related Experiment Videos

Human Insulinomas: Clinical, Cellular, and Molecular Aspects

Related Concept Videos

Professional development program to promote students' conceptual understanding through technology-enhanced teaching: a learner-centered evaluation.

Divergent c-MYC Expression Patterns in NET and NEC: Insights from a Multicentre Cohort of 1380 Neuroendocrine Neoplasms.

Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations.

Real-World-Feasible Immunohistochemistry of ATRX, DAXX, and Menin Identifies a Subgroup of Non-Functioning Pancreatic Neuroendocrine Tumors with low Recurrence Risk to Guide De-Escalating Surveillance.

Neuroendocrine Neoplasms of the Urinary Bladder: Integrating Molecular Advances into a Refined Classification System.

Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas.

Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas.

Immediate Neoumbilicoplasty Following Excision of a Symptomatic Umbilical Lipoma Using Local Tissue Rearrangement and Fascial Fixation: A Case Report.

Quercetin-loaded exosomes prevent endometrial fibrosis by downregulating EGFR.

Mapping immune cell metabolic reprogramming from mechanistic hotspots to translational directions: A bibliometric analysis with exploratory clinical evidence.

A triple-immunomodulatory quercetin nanoplatform to reinforce T-cell function and remodel tumor microenvironment.

Antigen-specific regulatory T cells eliminate cognate CD4 effector T cells through perforin, granzyme B, and Bim.

Mechanism of SGLT2 inhibitors in improving immune imbalance in diabetic mice with sepsis via regulating macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis.

Related Experiment Videos

Human Insulinomas: Clinical, Cellular, and Molecular Aspects

Related Concept Videos

Related Articles