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Related Experiment Videos

Mesenteric baroreceptors.

R S Tuttle, M McCleary

    The American Journal of Physiology
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Mesenteric Pacinian corpuscles act as baroreceptors, initiating vasomotor reflexes that inhibit skin and muscle blood flow. Cutting mesenteric nerves abolished these reflex changes, suggesting a neural pathway.

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    Area of Science:

    • Physiology
    • Neuroscience
    • Cardiovascular Research

    Background:

    • Vascular occlusion and catecholamine administration significantly alter blood flow in feline skin and muscle.
    • Previous research indicated potential baroreceptor involvement in regulating peripheral circulation.

    Purpose of the Study:

    • To identify the specific receptors and pathways responsible for vasomotor reflexes originating in the mesentery.
    • To elucidate the role of mesenteric receptors in regulating skin and muscle blood flow.

    Main Methods:

    • Occlusion of mesenteric vessels and catecholamine injection in cats.
    • Mesenteric nerve sectioning to assess reflex abolition.
    • Cross-perfused mesenteric preparations to evaluate hemodynamic factors.
    • Investigation of Pacinian corpuscle function in vivo.

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    Main Results:

    • Mesenteric vessel occlusion and catecholamine injection caused significant changes in skin and muscle blood flow.
    • These hemodynamic changes were abolished upon sectioning of the mesenteric nerves.
    • Cross-perfusion experiments ruled out systemic pressure and peripheral resistance changes as primary reflex initiators.
    • Evidence points to mesenteric Pacinian corpuscles as the likely baroreceptors initiating these vasomotor reflexes.

    Conclusions:

    • Mesenteric Pacinian corpuscles function as baroreceptors, initiating vasomotor reflexes.
    • These reflexes lead to the inhibition of vasomotor neurons supplying skin and muscle.
    • The findings highlight a novel neural pathway for cardiovascular regulation originating in the mesenteric vasculature.