Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Helicobacter pylori: consensus and controversy.

Douglas J Passaro1, E Julia Chosy, Julie Parsonnet

  • 1Division of Epidemiology and Biostatistics, University of Illinois-Chicago School of Public Health, Chicago, IL, 60612, USA. doug@uic.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|July 13, 2002
PubMed
Summary

Helicobacter pylori (H. pylori) infection causes various outcomes, with treatment recommended for specific conditions. Understanding H. pylori pathogenesis is key to refining treatment guidelines for asymptomatic infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Helicobacter pylori</i>, herpes simplex virus-1, varicella-zoster virus, and dementia risk.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Beyond Water, Rest, and Shade: Advancing Farmworker Heat Protection Through Partnership.

American journal of industrial medicine·2026
Same author

Dialysis Facility Closures in the US From 2018 to 2024: A Serial Cross-Sectional Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

<i>Helicobacter pylori</i> Screen-and-Treat Programs for Gastric Cancer Prevention - IARC Working Group Report.

The New England journal of medicine·2026
Same author

Flush with data: harnessing emergency department wastewater as an innovative approach for surveillance of infectious diseases.

American journal of epidemiology·2026
Same author

Pilot ED Wastewater Surveillance During the 2024-2025 Respiratory Virus Season.

JAMA network open·2026

Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Helicobacter pylori (H. pylori) is a bacterium that colonizes the human stomach, leading to diverse clinical outcomes.
  • Infection outcomes depend on bacterial strain, host factors, and environmental influences.
  • Eradication therapy is recommended for peptic ulcer disease, gastric lymphoma, or NSAID users, but carries risks like worsening GERD and increasing esophageal cancer risk.

Purpose of the Study:

  • To review the current understanding of H. pylori pathogenesis and its clinical implications.
  • To highlight the challenges and successes in H. pylori eradication therapy.
  • To emphasize the need for improved treatment strategies for H. pylori infections, particularly in asymptomatic individuals.

Main Methods:

Related Experiment Videos

  • Review of existing literature on H. pylori infection, pathogenesis, diagnosis, and treatment.
  • Analysis of factors influencing H. pylori-related diseases.
  • Examination of the impact of antibiotic resistance on eradication success.

    • Main Results:

    • H. pylori infections can be diagnosed noninvasively and eradicated with ~85% success using multidrug regimens.
    • Antibiotic resistance is a growing concern, impacting treatment effectiveness globally.
    • Current treatment guidelines are primarily for symptomatic H. pylori infections.

    Conclusions:

    • Further research into H. pylori pathogenesis variation is needed to guide treatment decisions.
    • Clearer recommendations for treating H. pylori in individuals without peptic ulcer disease or gastric lymphoma are required.
    • Optimizing H. pylori treatment strategies is crucial given increasing antibiotic resistance.