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Fenofibrate inhibits reactive amyloidosis in mice
Takehiro Murai1, Toshiyuki Yamada, Takashi Miida
1Niigata University School of Medicine, Asahimachi 1-757, Niigata 951-8510, Japan.
Objective:
To examine the effects of the lipid-lowering agent fenofibrate on experimental AA amyloidosis and on serum amyloid A (SAA) levels.
Methods:
Fenofibrate was administered orally in a mouse model of amyloidosis, which is induced by injections of amyloid-enhancing factor and Freund's complete adjuvant. Fenofibrate was given for 3 weeks, including a 1-week course before induction of amyloidosis. Splenic amyloid deposits were evaluated histologically, and SAA levels were measured.
Results:
Fenofibrate inhibited the formation of splenic amyloid deposits and suppressed the elevation of SAA levels. CONCLUSION; Fenofibrate inhibits experimental amyloidosis by reducing levels of the precursor SAA.