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Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

Production of Formed Elements

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

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Related Experiment Video

Updated: Jun 30, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

Haematopoietic stem cells.

Dominique Bonnet¹

¹Cancer Research UK, London Research Institute, London, UK.

The Journal of Pathology

|July 13, 2002

Summary

This summary is machine-generated.

Recent research reveals human hematopoietic stem cells (HSCs) are more diverse than previously thought, with new markers and genes identified. This advances understanding of HSC plasticity and potential clinical applications.

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Published on: June 16, 2019

Area of Science:

Hematology
Stem Cell Biology
Molecular Biology

Background:

Human hematopoietic stem cells (HSCs) are crucial for blood formation.
Recent studies highlight significant heterogeneity within the HSC compartment.
The universal marker CD34 does not identify all human HSCs.

Purpose of the Study:

To review recent advances in understanding human HSC composition and function.
To examine the implications of new discoveries for clinical applications and hematopoiesis.
To explore the molecular phenotype and plasticity of human HSCs.

Main Methods:

Literature review of recent studies on human HSCs.
Analysis of gene expression and cell surface marker data.
Synthesis of findings on HSC heterogeneity, plasticity, and regulation.

Main Results:

Human HSCs exhibit considerable heterogeneity in self-renewal and proliferation.
Novel markers for HSC purification beyond CD34 have been identified.
New genes regulating HSC formation, self-renewal, and differentiation have been discovered.
Unexpected developmental plasticity of HSCs has been observed.

Conclusions:

The molecular phenotype of human HSCs is complex and still under investigation.
Recent discoveries offer new avenues for clinical therapies and understanding hematopoiesis.
Further research is needed to fully elucidate HSC biology and harness its potential.