Anticipation in migraine with affective psychosis

Anticipation is the term given to the apparent occurrence of an inherited disorder at a progressively earlier age of onset in successive generations. A family of a mother and two children, a 17-year-old girl and a 13-year-old boy, all experienced migraine with affective psychosis. There is a strong genetic predisposition to the psychiatric disorder of affective psychosis along with a dominant pattern of migraine in the family, which suggests a genetic connection between migraine and affective psychosis.