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SNAPper: gene order predicts gene function.

Grigory Kolesov¹, Hans-Werner Mewes, Dmitrij Frishman

¹Institute for Bioinformatics, GSF-National Research Center for Environment and Heath, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. g.kolesov@gsf.de

Bioinformatics (Oxford, England)

|July 16, 2002

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SNAPper predicts gene function using conserved gene order. This network service aids in understanding gene roles across species through comparative genomics.

Area of Science:

Bioinformatics
Genomics
Computational Biology

Background:

Gene function prediction is crucial for understanding biological systems.
Conserved gene order (synteny) is a known indicator of functional relatedness.
Existing methods may not fully leverage synteny information.

Purpose of the Study:

To introduce SNAPper, a novel network service for gene function prediction.
To utilize the conservation of gene order as a primary predictive feature.
To provide a publicly accessible tool for genomic analysis.

Main Methods:

Developing a network service architecture for SNAPper.
Implementing algorithms to detect conserved gene order across genomes.
Integrating sequence similarity and synteny conservation for function prediction.

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Main Results:

SNAPper successfully predicts gene function based on conserved gene order.
The service demonstrates the utility of synteny in functional genomics.
Predictions are being integrated into the PEDANT genome analysis server.

Conclusions:

Conserved gene order is a powerful predictor of gene function.
SNAPper offers a valuable new approach to functional genomics.
The integration with PEDANT will enhance its accessibility and utility.