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Updated: Jul 20, 2026

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut
Published on: February 14, 2011
Borrelia burgdorferi and its tropisms for adhesion molecules in the joint
Jenifer Coburn1, Melisa Medrano, Carla Cugini
1New England Medical Center, Boston, Massachusetts 02111, USA. jcoburn@lifespan.org
Abstract:
Borrelia burgdorferi, the spirochete that causes Lyme disease, has evolved elegant strategies for interacting with its mammalian hosts. Among them are several distinct mechanisms of adhesion to cells and extracellular matrix components. The mammalian receptors for B. burgdorferi that have been most thoroughly studied, and for which candidate bacterial ligands have been identified, are decorin, fibronectin, glycosaminoglycans, and beta3-chain integrins. This diversity of adhesion mechanisms allows B. burgdorferi to infect multiple tissues, including the synovial tissues of the joints.
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