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[Venereal granuloma (donovaniasis) in France]
Abstract:
The study of six cases of MacLeod-Donovan chancre, 2 in Paris, 4 in Brest, in young men coming from the West Indies, showed after 15 days incubation, a balano-preputial lesion consisting of an oval-shaped granuloma, 1 to 4 cm diameter, raised, indurated, ulcerated, reddish-yellow, spontaneously painful, bleeding easily, accompanied in 50 p. 100 of cases by inguinal adenitis, due to secondary infection. Swabs, which should be repeated, showed Donovan bodies within numerous histiocytes. The inactivity of penicillin may be contrasted with the rapidly favourable effect of streptomycin, chloramphenicol or aureomycin.
Insights
MacLeod-Donovan chancre, a rare granuloma, presents with painful lesions and inguinal adenitis. Streptomycin, chloramphenicol, and aureomycin show favorable effects, unlike penicillin.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- MacLeod-Donovan chancre is a rare sexually transmitted infection.
- This study examines six cases in young men from the West Indies.
Observation:
- Lesions appeared after a 15-day incubation period.
- Observed balano-preputial granulomas (1-4 cm), raised, indurated, ulcerated, reddish-yellow, painful, and bleeding.
- Fifty percent of cases showed inguinal adenitis due to secondary infection.
Findings:
- Donovan bodies were identified within histiocytes in swabs.
- Penicillin demonstrated inactivity against the condition.
- Streptomycin, chloramphenicol, and aureomycin exhibited rapid, favorable therapeutic effects.
Implications:
- Highlights the diagnostic importance of identifying Donovan bodies.
- Suggests alternative antibiotic treatments when penicillin is ineffective.
- Informs clinical management of MacLeod-Donovan chancre, particularly in travelers from endemic regions.