Oxytetracycline concentration of bile after systemic and regional administration

Oxytetracycline concentration of bile was determined after systemic and regional (intraportal) infusions. A single dose of 3.60 mg/kg of oxytetracycline was infused into the brachial vein of 8 dogs and into the portal vein of 9 dogs in 120 minutes. Bile samples taken at 30, 60, 120 and 180 minutes showed that the liver excretes into the bile higher concentrations of oxytetracycline in the case of intraportal infusion. The results suggest that treatment of inflammatory diseases of bacterial origin of the biliary tree might be more effective when the antibiotic is applied in intraportal infusion.