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Poly(dimethylsiloxane) as a material for fabricating microfluidic devices.

J Cooper McDonald1, George M Whitesides

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Accounts of Chemical Research
|July 18, 2002
PubMed
Summary
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This Account reviews poly(dimethylsiloxane) (PDMS) microfluidic devices for biomedical applications. It details fabrication methods and device actuation, leveraging PDMS properties for simple construction and material integration.

Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Microfluidic devices are crucial for advanced biomedical applications.
  • Poly(dimethylsiloxane) (PDMS) is a versatile polymer for microfluidic device fabrication due to its unique properties.

Purpose of the Study:

  • To summarize fabrication techniques for PDMS-based microfluidic devices.
  • To highlight the applications of these devices in biomedicine.
  • To focus on utilizing PDMS's physical and chemical characteristics for device fabrication and actuation.

Main Methods:

  • Fabrication of microchannels within PDMS.
  • Incorporation of other materials and structures via encapsulation.
  • Sealing techniques (reversible and irreversible) for device assembly.

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Main Results:

  • PDMS offers a straightforward method for microchannel fabrication.
  • The polymer's properties enable diverse material integration.
  • Various sealing methods allow for adaptable device construction.

Conclusions:

  • PDMS microfluidics provide a simple yet powerful platform for biomedical research.
  • The material's properties facilitate innovative device designs and applications.
  • Further exploitation of PDMS characteristics can advance microfluidic technology in medicine.