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Common perinatal insults diminish cord blood RANTES
Benjamin Dekel1, Marina Rubinstein, Ram Mazkeret
1Department of Pediatric Intensive Care, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Biology of the Neonate
|July 18, 2002
Abstract:
We demonstrate that the cord blood RANTES concentrations are reduced in full-term newborns who were born from meconium-stained amniotic fluid as compared with full-term newborns born after normal delivery. Since RANTES inhibits immunodeficiency virus (HIV) entry into macrophages, thereby bestowing increased resistance to HIV (including protection in utero), we propose that common perinatal events might precipitate higher perinatal transmission of HIV.