Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lineage commitment and cellular differentiation in exocrine pancreas.

A L Means1, S D Leach

  • 1Departments of Surgery and Cell Biology, Vanderbilt University School of Medicine, Nashville, Tenn., USA.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|July 18, 2002
PubMed
Summary

Understanding pancreatic cell differentiation is key. Research explores how pluripotent stem cells give rise to endocrine and exocrine cell types, crucial for pancreas development and function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility.

Nature communications·2021
Same author

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells.

Oncogene·2015
Same author

Emerging strategies for cancer immunoprevention.

Oncogene·2015
Same author

Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey.

Oncogene·2014
Same author

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.

Oncogene·2013
Same author

Brain parenchymal signal abnormalities associated with developmental venous anomalies: detailed MR imaging assessment.

AJNR. American journal of neuroradiology·2008

Area of Science:

  • Developmental biology
  • Cell biology
  • Endocrinology

Background:

  • Exocrine pancreatic cells constitute over 90% of the adult pancreas.
  • Factors regulating acinar and ductal epithelial cell differentiation are not fully understood.
  • Both endocrine and exocrine cells originate from pluripotent precursors in embryonic pancreatic epithelium.

Purpose of the Study:

  • To investigate the regulatory factors governing pancreatic cell differentiation.
  • To explore the role of pluripotent stem cells in generating diverse pancreatic cell types.
  • To understand the signaling pathways balancing endocrine and exocrine lineage commitment.

Main Methods:

  • Analysis of embryonic pancreatic development.
  • Stem cell differentiation studies.

Related Experiment Videos

  • Signaling pathway investigation.

    • Main Results:

    • Evidence suggests a common pool of pluripotent stem cells generates both endocrine and exocrine pancreatic cells.
    • Specific signaling pathways are identified as critical regulators of lineage commitment.
    • A balance between endocrine and exocrine cell fates is maintained by these pathways.

    Conclusions:

    • Pluripotent stem cells are central to pancreatic cell type generation.
    • Signaling pathways play a vital role in directing stem cell fate towards endocrine or exocrine lineages.
    • Further research into these pathways can inform therapeutic strategies for pancreatic diseases.