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Pyrene-neomycin conjugate: dual recognition of a DNA triple helix

Liang Xue1, I Charles, Dev P Arya

  • 1Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, SC 29634, USA.

Chemical Communications (Cambridge, England)
|July 18, 2002
PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...