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Titanium-catalyzed enantioselective alkynylation of aldehydes
Gui Lu1, Xingshu Li, Wing Lai Chan
1Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong Polytechnic University, Hong Kong.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
A simple and practical method to make chiral propargylic alcohols has been developed: in the presence of a titanium alkoxide catalyst prepared in situ from titanium tetraisopropoxide and (R)-H8-binaphthol, a variety of aromatic aldehydes were converted to the corresponding chiral propargylic alcohols with very good enantioselectivities (up to 96.2% e.e.) and yields.