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Polyclonal antibody-catalysed hydrolysis of a beta-lactam
Elizabeth L Ostler1, Marina Resmini, Guillaume Boucher
1School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, UK BN2 4GJ.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
We report the first example of antibody-catalysed hydrolysis of a beta-lactam where the antibodies were generated by a simple transition-state analogue; in this example the antibodies are polyclonal.