Building drug delivery into tissue engineering
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Updated: Sep 30, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
Published on: October 4, 2017
W Mark Saltzman1, William L Olbricht
1School of Chemical Engineering, Cornell University, 120 Olin Hall, Ithaca, New York 14853, USA. saltzman@cheme.cornell.edu
Abstract:
The creation of efficient methods for manufacturing biotechnology drugs--many of which influence fundamental but complex cell behaviours, such as proliferation, migration and differentiation--is creating new opportunities for tissue repair. Many agents are potent and multifunctional; that is, they produce different effects within different tissues. Therefore, control of tissue concentration and spatial localization of delivery is essential for safety and effectiveness. Synthetic systems that can control agent delivery are particularly promising as materials for enhancing tissue regeneration. This review discusses the state of the art in controlled-release and microfluidic drug delivery technologies, and outlines their potential applications for tissue engineering.
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