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Updated: Aug 10, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
Published on: April 11, 2012
Development of therapeutics: opportunities within complementary and alternative medicine
Linda W Engel1, Stephen E Straus
1National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health, 31 Center Drive, Bethesda, Maryland 20892, USA. engell@od.nih.gov
Abstract:
Whereas other components of the National Institutes of Health support the discovery and subsequent development of novel chemical entities into drugs, the National Center for Complementary and Alternative Medicine (NCCAM) studies complex natural products that are marketed as dietary supplements. This article contrasts the regulatory framework for dietary supplements and drugs, outlines the challenges of evaluating dietary supplements for safety and clinical effectiveness, and describes the evolving drug model for botanicals.
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