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Synthesis of D-erythro-sphingosine and D-erythro-ceramide
Jacqueline E Milne1, Krzysztof Jarowicki, Philip J Kocienski
1Department of Chemistry, Leeds University, Leeds, UK LS2 9JT.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
A 1,2-metallate rearrangment of a higher order cuprate derived from an alpha-lithiated xylal derivative and tridecyllithium is the key step in a synthesis of D-erythro-sphingosine and ceramide. A convenient method for preparing alpha-lithiated glycals from alpha-phenylsulfinyl glycals is also described.