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Solid-phase synthesis of apicidin A and a cyclic tetrapeptoid analogue
Frédéric Berst1, Mark Ladlow, Andrew B Holmes
1GSK Cambridge Technology Centre, Lensfield Road, Cambridge, UK CB2 1EW.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
The solid-phase synthesis of the antiprotozoal cyclic tetrapeptide apicidin A is reported and its synthetic accessibility is contrasted with that of a structurally similar reduced cyclic tetrapeptoid analogue.