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Related Experiment Videos

Histopathologic study on pulp response to single-bottle and self-etching adhesive systems.

Vicente O Medina1, Koichi Shinkai, Manabu Shirono

  • 1Department of Clinical Dental Health Sciences, College of Dentistry, University of the Philippines Manila. giamed@hotmail.com

Operative Dentistry
|July 18, 2002
PubMed
Summary

Seven adhesive resins were compared to calcium hydroxide for pulp response in monkeys. Some resins showed similar healing, but calcium hydroxide promoted faster reparative dentin formation.

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Area of Science:

  • Dental Materials Science
  • Biomaterials
  • Regenerative Dentistry

Background:

  • Adhesive resins are increasingly used in direct pulp capping procedures.
  • Evaluating their biocompatibility and efficacy in promoting pulp healing is crucial.
  • Comparison with established materials like calcium hydroxide provides a benchmark.

Purpose of the Study:

  • To compare the pulp response to seven adhesive resin systems versus calcium hydroxide.
  • To assess histopathological outcomes including tissue disorganization, inflammation, and reparative dentin formation.
  • To investigate the correlation between inflammatory response and bacterial presence.

Main Methods:

  • Exposed monkey pulps were capped with Dycal (calcium hydroxide) or one of seven adhesive resin systems.

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  • Histopathological evaluation was performed at 3, 30, and 90 days post-operation.
  • Statistical analysis included Kruskal-Wallis and Least Significant Difference tests; Kendall correlation was used for inflammation-bacteria relationship.

    • Main Results:

    • Four adhesive resins (Single Bond, One Step, Perme Bond F, One-up Bond F) showed pulp responses comparable to calcium hydroxide.
    • Calcium hydroxide (Dycal) group exhibited earlier and more complete reparative dentin bridge formation.
    • Three adhesive resins (AQ Bond, Imperva Fluorobond, Prime&Bond NT) induced significantly higher inflammation and less reparative dentin.

    Conclusions:

    • Certain adhesive resins demonstrate biocompatibility similar to calcium hydroxide for direct pulp capping.
    • Calcium hydroxide remains superior in promoting faster and more complete dentin bridge formation.
    • A significant correlation exists between inflammatory cell infiltration and bacterial presence in pulp exposure sites.