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Related Experiment Videos

Vancomycin-resistant Staphylococcus aureus: a real and present danger?

J M Hamilton-Miller1

  • 1Dept. of Medical Microbiology, Royal Free and University College Medical School, London, UK. j.hamilton-miller@rfc.ucl.ac.uk

Infection
|July 18, 2002
PubMed
Summary
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Reduced susceptibility to vancomycin (or glycopeptide)-intermediate Staphylococcus aureus (VISA) is a growing concern. Early detection and judicious use of antibiotics are crucial to prevent the spread of VISA strains.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Glycopeptide antibiotics (vancomycin, teicoplanin) are critical for treating methicillin-resistant Staphylococcus aureus (MRSA).
  • Increasing global reports of Staphylococcus aureus with reduced glycopeptide susceptibility (VISA) are linked to prolonged therapy.
  • Conventional disk sensitivity tests may fail to detect VISA, hindering monitoring.

Purpose of the Study:

  • To highlight the challenge of detecting and monitoring VISA strains.
  • To emphasize the need for effective control measures against VISA.
  • To advocate for judicious glycopeptide use and introduce alternative antibiotics.

Main Methods:

  • Review of clinical isolates and susceptibility testing data.

Related Experiment Videos

  • Analysis of trends in VISA occurrence worldwide.
  • Evaluation of diagnostic limitations for VISA detection.

    • Main Results:

    • VISA strains are increasingly reported globally, often after extended glycopeptide treatment.
    • Standard susceptibility tests can miss VISA, complicating surveillance.
    • Alternative antibiotics like quinupristin/dalfopristin and linezolid offer options for resistant strains.

    Conclusions:

    • Effective strategies are needed to curb the rise and spread of VISA in healthcare and communities.
    • Judicious use of glycopeptides is a key component of control.
    • Newer antibiotics can support the judicious use of glycopeptides.