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Low-molecular-weight heparin for vertebral artery dissection
Marco Marietta1, Marcello Bertesi, Nino Rozzi
1Department of Medical Sciences, University of Modena and Reggio Emilia, Italy. marietta@unimo.it
Summary
A pediatric case of vertebral artery dissection and basilar artery thrombosis was successfully treated with enoxaparin. This low-molecular-weight heparin therapy led to complete recanalization, demonstrating its safety and efficacy in young patients.
Area of Science:
- Neurology
- Pediatric Neurology
- Vascular Neurology
Background:
- Vertebral artery dissection (VAD) and subsequent basilar artery thrombosis (BAT) are rare but serious conditions in pediatric patients.
- Prompt diagnosis and effective anticoagulation are critical for favorable outcomes.
Observation:
- A 6-year-old patient presented with VAD and consequent BAT.
- The patient received therapeutic doses of subcutaneous low-molecular-weight heparin (enoxaparin).
Findings:
- Treatment involved enoxaparin at 100 IU/kg twice daily for 3 weeks, followed by 2,000 IU/day for 3 weeks.
- Follow-up magnetic resonance angiography confirmed complete recanalization of the basilar artery.
Implications:
- Enoxaparin is a safe and effective therapeutic option for pediatric thrombosis associated with vertebral artery dissection.
- This case highlights the successful management of a rare cerebrovascular event in a child.