Related Experiment Video
Updated: Jul 7, 2026
13:58
Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics
Published on: September 28, 2016
Asymmetric sulfoxidation and amine binding by H64D/V68A and H64D/V68S Mb: mechanistic insight into the chiral
Shigeru Kato1, Hui-Jun Yang, Takafumi Ueno
1Department of Structural Molecular Science, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan.
Journal of the American Chemical Society
|July 18, 2002
Abstract:
The H64D/V68A and H64D/V68S mutants of Myoglobin are found to oxidize thioanisole with high enantioselectivity and reactivity. These mutants are also capable of enantioselective binding of alpha-methylbenzylamine, which mimics an expected sulfoxidation intermediate. The kinetic study of the amine binding shows that the Fe-O bond cleavage in the intermediate may be the chiral discrimination step of the sulfoxidation.
