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CD80 (B7-1) and CD86 (B7-2) genes and genetic susceptibility to coeliac disease
N Woolley1, P Holopainen, C Bourgain
1Department of Tissue Typint, finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Abstract:
The role of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in T-cell activation makes them good candidates for coeliac disease susceptibility genes. We conducted a genetic linkage study of the CD80/86 gene region in the general Finnish population and in a local subisolate. No linkage was found in either population.