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Biguanide-atovaquone synergy against Plasmodium falciparum in vitro
1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L35QA, United Kingdom.
Antimicrobial Agents and Chemotherapy
|July 18, 2002
Abstract:
The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. All five biguanides tested interacted synergistically with atovaquone against Plasmodium falciparum in vitro. All of the other compounds tested were either additive or antagonistic.