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Updated: Aug 15, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
High diastereoselectivity in intermolecular carbonyl ylide cycloaddition with aryl aldehyde using methyl
Biao Jiang1, Xiaobing Zhang, Zhaohui Luo
1The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China. jiangb@pub.sioc.ac.cn
Abstract:
[reaction: see text] Methyl diazo(trifluoromethyl)acetate undergoes Rh2(OAc)4 catalyzed reaction with aryl aldehyde to form 1,3-dioxolanes bearing a C-4 trifluoromethyl group diastereoselectively in excellent yield.
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