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Ci proteolysis: regulation by a constellation of phosphorylation sites
Mark A Lefers1, Robert Holmgren
1Department of Biochemistry, Molecular Biology and Cell Biology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 2153 Sheridan Road, Evanston, Illinois 60208, USA.
Current Biology : CB
|July 19, 2002
Abstract:
Proteolytic processing of Ci requires phosphorylation by the kinases Sgg/GSK3 and CK1. The newly identified phosphorylation sites form clusters with previously described PKA sites in which phosphorylation by PKA acts to prime subsequent phosphorylation by Sgg/GSK3 and CK1.