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Head, neck, and spines: a role for LIMK-1 in the hippocampus
Patrick D Sarmiere1, James R Bamburg
1Department of Biochemistry and Molecular Biology, Program in Molecular, Cellular and Integrative Neuroscience, Colorado State University, Fort Collins 80523, USA.
Neuron
|July 19, 2002
Abstract:
LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings are consistent with a role for LIMK-1 in synapse formation and function.