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Updated: Oct 8, 2026

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
Published on: September 17, 2012
The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator
Niklas Schier1, Reinhard Fischer
1Department of Microbiology, Philipps-University of Marburg and Max-Planck-Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, 35043, Marburg, Germany.
Abstract:
The filamentous fungus Aspergillus nidulans reproduces asexually through conidiospores, which are continuously generated at morphologically differentiated structures, the conidiophores. In contrast to vegetative, multinucleate cells, spore formation requires a strict coordination of mitosis and cytokinesis. It was shown recently that the key regulator of the cell cycle in A. nidulans NimX(Cdc2) and a G(1)/S cyclin, PclA, are transcriptionally upregulated during development. Here we show that PclA accumulates in the nucleus and interacts with NimX(Cdc2). We propose that PclA modulates the kinase activity of NimX(Cdc2) during spore formation.
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