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Experimental diphtheritic neuropathy in the mouse: a study in cellular resistance.

R Mellick, L Dolan, A D Kidman

British Journal of Experimental Pathology

|October 1, 1975

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Diphtheria toxin causes demyelination in mouse sciatic nerves when injected directly. Significantly higher doses are needed in mice compared to chickens to induce nerve damage.

Area of Science:

Neuroscience
Toxicology

Background:

Diphtheria toxin is known to cause various neurological effects.
The susceptibility of peripheral nerves to toxins can vary between species.

Purpose of the Study:

To investigate the effects of direct intraneural injection of diphtheria toxin on the mouse sciatic nerve.
To compare the dose-response relationship of diphtheria toxin-induced demyelination in mice versus chickens.

Main Methods:

Direct intraneural injection of diphtheria toxin into the sciatic nerve of mice.
Histological examination of nerve tissue to assess demyelination.
Comparison of effective doses with previously reported data in chickens.

Main Results:

Diphtheria toxin administration induced demyelination in the mouse sciatic nerve.

Related Experiment Videos

A dose approximately 2 million times greater (on an equal weight of nerve basis) was required to produce lesions in mice compared to chickens.

Conclusions:

The mouse sciatic nerve is significantly less sensitive to diphtheria toxin-induced demyelination than the chicken sciatic nerve.
Species-specific differences in nerve susceptibility to diphtheria toxin are substantial.