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Physiological functions of imprinted genes.

Benjamin Tycko1, Ian M Morison

  • 1Institute for Cancer Genetics, Columbia University, New York, New York, USA. bt12@columbia.edu

Journal of Cellular Physiology
|July 19, 2002
PubMed
Summary

Genomic imprinting, a process of parent-specific gene expression, influences mammalian growth and brain function. Research explores its biological rationale, compiling data on imprinted genes.

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Area of Science:

  • Genetics
  • Developmental Biology
  • Epigenetics

Background:

  • Genomic imprinting establishes parent-of-origin-dependent gene expression in mammals.
  • Early studies in mice revealed imprinting's role in growth and behavior, but not severe malformations.

Purpose of the Study:

  • To review evidence linking imprinted genes to growth, brain function, and behavior.
  • To explore the biological rationale behind genomic imprinting.
  • To present a comprehensive database of imprinted genes.

Main Methods:

  • Review of existing embryological and genetic experimental data.
  • Analysis of identified and manipulated individual imprinted genes.
  • Compilation of a comprehensive database of imprinted genes.

Main Results:

  • Imprinted genes primarily regulate pre- and post-natal growth.
  • Evidence suggests a role for imprinted genes in brain function and behavior.
  • A comprehensive database is available for further research.

Conclusions:

  • Genomic imprinting significantly impacts mammalian development, particularly growth and neurobehavior.
  • Further investigation into the compiled data may elucidate a coherent biological rationale for imprinting.
  • The database serves as a valuable resource for understanding imprinted gene function.

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