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Related Experiment Videos

Prophylactic bilateral mastectomy: patterns of practice.

Kelly A Metcalfe1, Vivek Goel, Lavina Lickley

  • 1The Centre for Research in Women's Health, Toronto, Ontario, Canada.

Cancer
|July 19, 2002
PubMed
Summary

Prophylactic mastectomy is uncommon, with most procedures performed due to family history or BRCA mutations. Genetic testing may influence future patterns for this breast cancer risk-reducing surgery.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Genetics

Background:

  • Elevated risk of breast carcinoma prompts prophylactic mastectomy.
  • Population-based study in Ontario, Canada, examines prophylactic mastectomy practices since 1991.

Purpose of the Study:

  • To review indications for prophylactic mastectomy.
  • To analyze patterns of practice for prophylactic mastectomy.

Main Methods:

  • Medical chart review at 33 hospitals performing prophylactic mastectomies.
  • Inclusion criteria: bilateral mastectomy patients without breast carcinoma diagnosis.

Main Results:

  • Prophylactic bilateral mastectomies ranged from 6 to 19 annually.
  • Mean age of patients was 43.5 years.

Related Experiment Videos

  • 80% of procedures were due to family history or BRCA1/BRCA2 mutations; 20% for benign breast conditions.
  • Total mastectomy (89%) was more common than subcutaneous mastectomy (11%) for those with family history.
  • 60% of patients had reconstructive surgery.

    • Conclusions:

    • Prophylactic mastectomy is not widely performed.
    • Genetic testing for BRCA1 and BRCA2 may alter future practice patterns.