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Updated: Sep 30, 2026

High Resolution Phonon-assisted Quasi-resonance Fluorescence Spectroscopy
Published on: June 28, 2016
Nonlinearity in optical resolution via distillation applying mixtures of resolving agents
Imre Markovits1, Gabriella Egri, Elemér Fogassy
1Department of Organic Chemical Technology, Budapest University of Technology and Economics, Budapest, Hungary.
Abstract:
During an optical resolution it is the resolving agent that has the strongest influence on the outcome of the process. Applying a mixture of resolving agents can result either in antagonism or in synergy. We found that using mixtures of tartaric acid and its derivatives chiral selectivity is at least the same, but in several cases markedly better (synergistic effect), than the sum of the effect of the individual resolving agents. Thus, the "Dutch method," reported for the crystallization method, also works for distillation. A calculation method is applied for measuring the synergistic effect. Interestingly, an individually inactive resolving agent can be a useful contributor to the mixture of the resolving agents.
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