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Updated: Jul 19, 2026

Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala
Published on: April 15, 2016
[Activation of glutamate ionotropic connections of sensorimotor cortex neurons during conditioning]
V M Storozhuk1, V I Khorevin, N N Razumna
1Bogomolets Institute of Physiology, Ukrainian National Academy of Sciences, Kiev, Ukraine.
Abstract:
Changes in conditioned impulse reactions of neurons in sensorimotor cortex were studied during microiontophoretic application of glutamatergic and GABA ergic agonistic and antagonistic drugs. It was shown that ionotropic glutamate receptors (AMPA and NMDA) are activated by a conditioned stimulus. Not only large pyramidal neurons of deep cortical layers but surrounding short-axon inhibitory interneurons are involved in the reaction. It was shown that the activity of pyramidal neurons is under a constant inhibitory control from surrounding interneurons. This inhibition is involved in organization of excitatory cortical responses during conditioning.
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