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The effect of cigarette smoking on ceruloplasmin and C3 complement: risk of cardiovascular disease (atherosclerosis)

Rungsunn Tungtrongchitr1, Praneet Pongpaew, Benjaluck Phonrat

  • 1Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Asian Pacific Journal of Allergy and Immunology
|July 20, 2002
PubMed

Insights

Smoking significantly alters key blood proteins. Smokers show higher ceruloplasmin and lower albumin levels, potentially increasing cardiovascular disease risk.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Cardiovascular Health

Background:

  • Smoking impacts physiological markers.
  • Understanding protein level changes in smokers is crucial for health risk assessment.

Purpose of the Study:

  • To investigate serum concentrations of ceruloplasmin, C3 complement, and albumin in male smokers versus non-smokers.
  • To explore associations between smoking quantity, age, and these protein levels.

Main Methods:

  • Comparative analysis of serum protein levels (ceruloplasmin, C3 complement, albumin) in 119 male smokers and 65 male non-smokers.
  • Statistical examination of correlations between smoking habits, age, and measured protein concentrations.

Main Results:

  • Smokers exhibited significantly higher serum ceruloplasmin concentrations compared to non-smokers.
  • Smokers demonstrated statistically significant lower serum albumin concentrations.
  • Positive correlation observed between serum ceruloplasmin and C3 complement; associations found between smoking quantity and albumin levels.

Conclusions:

  • Elevated serum ceruloplasmin in smokers may indicate an acute-phase response.
  • These findings suggest potential increased risk for atherosclerosis and cardiovascular disease in smokers due to altered protein profiles.

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