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Isolation of Human Islets from Partially Pancreatectomized Patients

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Published on: July 30, 2011

Gallbladder disorders and type 2 diabetes mellitus--a clinic-based study.

P G Raman¹, A Patel, V Mathew

¹Department of Medicine, MGM Medical College and MY Hospital, Indore.

The Journal of the Association of Physicians of India

|July 20, 2002

Summary

Type 2 diabetes significantly increases gallbladder disorder prevalence, with higher fasting volumes and reduced contractions. Autonomic neuropathy and longer diabetes duration are contributing factors.

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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

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Published on: April 26, 2019

Area of Science:

Gastroenterology
Endocrinology
Diabetology

Background:

Type 2 diabetes is a global health concern.
Gallbladder disorders are common comorbidities.
Understanding the link between diabetes and gallbladder issues is crucial for patient management.

Purpose of the Study:

To determine the prevalence of gallbladder disorders in type 2 diabetes patients.
To investigate correlations between gallbladder disorders and patient factors such as age, sex, weight, diabetes duration, and autonomic neuropathy.

Main Methods:

Real-time ultrasonography was used to assess gallbladder disorders in 50 type 2 diabetic patients and 30 healthy controls.
Fasting gallbladder volume and post-meal contraction were measured and compared between groups.
Correlations were analyzed between gallbladder disorders and various patient characteristics.

Main Results:

Gallbladder disorders were found in 32% of diabetic patients versus 6.7% of controls.
Diabetic patients exhibited increased fasting gallbladder volume (26.2 cm³ vs 15.8 cm³) and reduced gallbladder contractions (53.1% vs. not specified).
Higher prevalence was observed in females (73.7%), with longer diabetes duration and autonomic neuropathy correlating with increased fasting volume.

Conclusions:

Type 2 diabetes is associated with a higher prevalence of gallbladder disorders.
Autonomic neuropathy partially explains increased fasting gallbladder volume in diabetics.
Further research is needed to explore other factors like cholecystokinin levels and gallbladder smooth muscle sensitivity.