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New routes to N-alkylated cyclic sulfamidates
Jeffrey J Posakony1, John R Grierson, Timothy J Tewson
1University of Iowa, PET Imaging Center, Department of Radiology, 0911Z JPP, 200 Hawkins Drive, Iowa City, Iowa, 52242-1007, USA.
The Journal of Organic Chemistry
|July 20, 2002
Abstract:
BOC- and dibenzosuberyl-protected chiral and hindered cyclic sulfamidates ([1,2,3]-oxathiazolidine-2,2-dioxides) were synthesized and subsequently deprotected using trifluoroacetic acid. The resulting crystalline sulfamidates were then used in several alkylation reactions involving benzyl bromide and alcohols in a versatile route to cyclic sulfamidates with differing N-alkyl substituents.