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Updated: Sep 30, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
The tachykinin NK-2 receptor antagonist SR48968 does not block noncholinergic contractions in unstable human bladder
Kate H Moore1, David S H Lam, William Lynch
1The Detrusor Muscle Laboratory, Pitney Clinical Sciences Building, Pelvic Floor Unit, St. George Hospital, Kogarah, NSW 2217, Sydney, Australia. k.moore@unsw.edu.au
Abstract:
Concentration-response curves to acetylcholine, and responses to electrical field stimulation (EFS) were compared in detrusor muscle strips, from control patients and those with idiopathic detrusor instability (IDI). Responses were similar in both groups. However, atropine abolished responses to EFS in 80% of control but only 33% of IDI patients (P>0.05), with the residual atropine-resistant response in most IDI patients abolished by tetrodotoxin. The post-atropine residual response was unaffected by the tachykinin NK-2 receptor antagonist SR48968. Despite the known existence of NK-2 receptors in the human detrusor, there was no evidence for tachykinin contribution to EFS-induced contractions.
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