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Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway
Marina Miller1, Jae Youn Cho, Kwang Je Baek
1Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0635, USA.
Abstract:
Respiratory syncytial virus (RSV) is an important cause of childhood respiratory disease as well as exacerbations of asthma. Although previous studies have demonstrated that a DNA vaccine encoding the RSV G protein can inhibit RSV replication in mouse models of RSV infection, studies have not been performed to determine whether a DNA vaccine encoding the RSV G protein can protect against RSV induced mucus expression and airway hyperresponsiveness which was the focus of this study. The DNA-G vaccine we constructed significantly inhibited RSV viral replication, mucus expression, and importantly was associated with inhibition of RSV induced airway responsiveness.