Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gap junctions in CO(2)-chemoreception and respiratory control.

Irene C Solomon1, Jay B Dean

  • 1Department of Physiology and Biophysics, State University of New York at Stony Brook, , Stony Brook, NY 11794-8661, USA. icsolomon@physiology.pnb.sunysb.edu

Respiratory Physiology & Neurobiology
|July 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Respiratory dysfunction in neurological disease and injury: novel mechanisms and potential therapeutics.

Frontiers in physiology·2025
Same author

Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping.

Journal of neurophysiology·2024
Same author

Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping.

bioRxiv : the preprint server for biology·2023
Same author

Initiating daily acute intermittent hypoxia (dAIH) therapy at 1-week after contusion spinal cord injury (SCI) improves lower urinary tract function in rat.

Experimental neurology·2022
Same author

The O<sub>2</sub>-sensitive brain stem, hyperoxic hyperventilation, and CNS oxygen toxicity.

Frontiers in physiology·2022
Same author

Seizures Caused by Exposure to Hyperbaric Oxygen in Rats Can Be Predicted by Early Changes in Electrodermal Activity.

Frontiers in physiology·2022
Same journal

Weighted Gene Co-expression Network Analysis of Early-Life PM₂.₅-Exposed Lung Transcriptome Identifies Key Gene Modules and Hub Genes Associated with Developmental Programming of COPD Vulnerability.

Respiratory physiology & neurobiology·2026
Same journal

Physiological responses during a maximal dry static breath-hold in a world champion freediver.

Respiratory physiology & neurobiology·2026
Same journal

Intermittent Hypoxemia in Preterm Infants: Glial Fibrillary Acidic Protein as a Potential Brain Injury Biomarker.

Respiratory physiology & neurobiology·2026
Same journal

Asymmetry of thoracic expansion in hemiplegic stroke and its relationship with physical function and percent vital capacity: A cross-sectional study.

Respiratory physiology & neurobiology·2026
Same journal

Evaluating the shape of the expiratory flow volume curve in asymptomatic ex-smokers.

Respiratory physiology & neurobiology·2026
Same journal

Emphysema and airway disease synergistically impair exercise tolerance in smokers: A CT-based study.

Respiratory physiology & neurobiology·2026
See all related articles

Gap junctions are crucial for mammalian central nervous system (CNS) functions, particularly in respiratory control. This review highlights their role in CO2 chemoreception and respiratory rhythm generation.

Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • Gap junctions, crucial for intercellular communication, are increasingly recognized for their significant role in the mammalian central nervous system (CNS).
  • Their involvement in vital functions like respiratory control was previously underestimated.

Purpose of the Study:

  • To review the neurobiology of gap junctions in the mammalian CNS.
  • To present evidence for the role of gap junctions in central CO2 chemoreception and respiratory control.

Main Methods:

  • Review of existing anatomical and electrophysiological studies.
  • Synthesis of evidence from neonatal and adult rodent models.

Main Results:

  • Gap junctions are integral to various aspects of respiratory control.

Related Experiment Videos

  • Evidence supports their involvement in central CO2 chemoreception.
  • Gap junctions influence respiratory rhythmogenesis and motoneuron output.

    • Conclusions:

    • Gap junctions play a prominent and multifaceted role in mammalian respiratory control.
    • Further research into gap junction function in the CNS is warranted.