Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein structure prediction in 2002.

Jack Schonbrun1, William J Wedemeyer, David Baker

  • 1Howard Hughes Medical Institute and Department of Biochemistry, Box 357350, University of Washington, Seattle, Washington 98165, USA.

Current Opinion in Structural Biology
|July 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CASP11 refinement experiments with ROSETTA.

Proteins·2015
Same author

Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.

Protein science : a publication of the Protein Society·2015
Same author

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy.

Proceedings of the National Academy of Sciences of the United States of America·2015
Same author

Mechanistic Analysis of an Engineered Enzyme that Catalyzes the Formose Reaction.

Chembiochem : a European journal of chemical biology·2015
Same author

Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces.

Science (New York, N.Y.)·2015
Same author

Designing Two-Dimensional Protein Arrays through Fusion of Multimers and Interface Mutations.

Nano letters·2015
Same journal

Tomogram exploration through template matching and deep learning.

Current opinion in structural biology·2026
Same journal

A comparative review of cryo-electron ptychography: Biological applications and future perspectives.

Current opinion in structural biology·2026
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
See all related articles

The fourth community-wide protein structure prediction experiment (CASP4) highlighted key challenges in protein structure prediction. Progress was made in automated remote homolog detection and de novo prediction, but high-resolution modeling needs improvement.

Area of Science:

  • Computational biology
  • Structural bioinformatics
  • Protein science

Background:

  • The fourth Community-wide Experiment on the Assessment of Protein Structure Prediction (CASP4) provided a comprehensive overview of the field.
  • Protein structure prediction is crucial for understanding protein function and biological processes.

Purpose of the Study:

  • To summarize the key findings and challenges highlighted by the CASP4 experiment.
  • To assess the progress in various protein structure prediction methodologies.

Main Methods:

  • Analysis of results from the CASP4 experiment.
  • Evaluation of different approaches including comparative modeling, remote homolog detection, and de novo prediction.

Main Results:

Related Experiment Videos

  • Sequence/structure alignment remains a significant bottleneck in comparative modeling.
  • Substantial advancements were observed in fully automated remote homolog detection.
  • Progress was also noted in de novo structure prediction techniques.

Conclusions:

  • Further significant progress in protein structure prediction necessitates improvements in high-resolution modeling.
  • The CASP4 experiment identified critical areas for future research and development in the field.