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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
Published on: October 19, 2021
Structural genomics of proteins from conserved biochemical pathways and processes
Stephen K Burley1, Jeffrey B Bonanno
1Howard Hughes Medical Institute, Laboratories of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. sburley@stromix.com
Current Opinion in Structural Biology
|July 20, 2002
Summary
Structural genomics programs are accelerating the characterization of biochemical pathways. Advances in X-ray crystallography and NMR spectroscopy provide insights into enzyme evolution and function in key metabolic pathways.
Area of Science:
- Biochemistry
- Structural Biology
- Genomics
Background:
- Significant progress has been made in characterizing conserved biochemical pathways.
- Structural genomics programs aim to accelerate the study of important proteins.
Purpose of the Study:
- To highlight advances in structural characterization of biochemical pathways.
- To demonstrate the utility of structural genomics in understanding enzyme function.
Main Methods:
- X-ray crystallography
- Solution Nuclear Magnetic Resonance (NMR) spectroscopy
- High-throughput protein production and crystallization
- Homology modeling
- Functional annotation
Main Results:
- Accelerated structural studies of biologically and medically important proteins.
- Provided insights into enzyme evolution and function.
- Characterized enzymes in isoprenoid biosynthesis and ribulose monophosphate pathways.
Conclusions:
- Structural genomics programs are effective in advancing biochemical pathway characterization.
- These methods offer valuable insights into enzyme evolution and function.
- The study underscores the importance of integrated structural and functional analyses.
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